Yet another study in mice, this time finding another suggestions as to why some on the autistic spectrum may find cannabinoids useful.
Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain
|IMAGE: This image shows an inhibitory neuron whose function is affected by neuroligin mutation.|
Mutations found in individuals with autism block the action of molecules made by the brain that act on the same receptors that marijuana’s active chemical acts on, according to new research reported online April 11 in the Cell Press journal Neuron. The findings implicate specific molecules, called endocannabinoids, in the development of some autism cases and point to potential treatment strategies.
“Endocannabinoids are molecules that are critical regulators of normal neuronal activity and are important for many brain functions,” says first author Dr. Csaba Földy, of Stanford University Medical School. “By conducting studies in mice, we found that neuroligin-3, a protein that is mutated in some individuals with autism, is important for relaying endocannabinoid signals that tone…
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