Researchers in Naples have found some differences in the average autistic child’s endocannabinoid system. Having more CB2 receptors (Both Cannabidiol and THC bind to this receptor), may explain why many autistic people find cannabis useful, and also why it doesn’t seem to matter too much whether it’s THC or CBD or both in many cases. More research is needed.
Cannabinoid Receptor Type 2, but not Type 1, is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders.
Division of Pharmacology, Department of Experimental Medicine, Second University of Naples, via S. Maria di Costantinopoli, 16, 80138, Naples, Italy, firstname.lastname@example.org.
Autistic disorders (ADs) are heterogeneous neurodevelopmental disorders arised by the interaction of genes and environmental factors. Dysfunctions in social interaction and communication skills, repetitive and stereotypic verbal and non-verbal behaviours are common features of ADs.
There are no defined mechanisms of pathogenesis, rendering curative therapy very difficult. Indeed, the treatments for autism presently available can be divided into behavioural, nutritional and medical approaches, although no defined standard approach exists.
Autistic children display immune system dysregulation and show an altered immune response of peripheral blood mononuclear cells (PBMCs).
In this study, we investigated the involvement of cannabinoid system in PBMCs from autistic children compared to age-matched normal…
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